CPT 45385
Global 000 ActiveColonoscopy w/lesion removal
CPT 45385 Billing & Documentation Guide
CPT code 45385 (Colonoscopy w/lesion removal) is classified under Surgery (Digestive) with a global period indicator of 000. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 4.46, a non-facility practice expense RVU of 10, and a malpractice RVU of 0.51, a total non-facility RVU of 14.97 and facility RVU of 6.69. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $515.18, though rates vary from $444.65 to $656.13 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 45385, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 45385 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
Endoscopic or minor procedure with related preoperative and postoperative work performed on the same day
MUE Limit (Medically Unlikely Edits)
Submitting more than 1 units of 45385 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 45385
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 4.46 | 4.46 |
| Practice Expense RVU | 10 | 1.72 |
| Malpractice RVU | 0.51 | 0.51 |
| Total RVU | 14.97 | 6.69 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 45385
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $558.77 | $231.52 | $526.7 - $656.13 | 29 |
| Florida | $517.25 | $239.77 | $493.88 - $539.75 | 3 |
| Georgia | $488.22 | $224.38 | $467.21 - $509.23 | 2 |
| Illinois | $504.78 | $237.55 | $480.54 - $524.78 | 4 |
| Michigan | $486.58 | $226.89 | $473.15 - $500.01 | 2 |
| North Carolina | $471.48 | $213.45 | $471.48 - $471.48 | 1 |
| New York | $551.81 | $243.28 | $478.25 - $587.27 | 5 |
| Ohio | $471.09 | $218.59 | $471.09 - $471.09 | 1 |
| Pennsylvania | $495.68 | $224.79 | $471.69 - $519.67 | 2 |
| Texas | $494.44 | $222.17 | $468.74 - $517.74 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 45385
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 45385 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 00731 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00732 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00740 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00810 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00811 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00812 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 00813 | Column 1 (primary), can be billed with modifier | No | Anesthesia service included in surgical procedure |
| 0184T | Column 1 (primary), can be billed with modifier | No | More extensive procedure |
| 0213T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0216T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
Frequently Asked Questions, CPT 45385
What does CPT code 45385 mean? +
CPT code 45385 represents: Colonoscopy w/lesion removal. It's in the Surgery (Digestive) category with a global period of 000.
What is the Medicare reimbursement for CPT 45385? +
The 2026 Medicare national average non-facility payment for CPT 45385 is $515.18. Rates range from $444.65 to $656.13 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 45385? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 45385? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on May 31, 2026.
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