CPT 44721
Global XXX ActivePrep donor intestine/artery
CPT 44721 Billing & Documentation Guide
CPT code 44721 (Prep donor intestine/artery) is classified under Surgery (Digestive) with a global period indicator of XXX. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 6.83, a non-facility practice expense RVU of 1.66, and a malpractice RVU of 1.82, a total non-facility RVU of 10.31 and facility RVU of 10.31. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $342.69, though rates vary from $299.97 to $439.58 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 44721, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 44721 with related codes; this code has 4 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
No global period (E/M and other non-procedural services)
MUE Limit (Medically Unlikely Edits)
Submitting more than 2 units of 44721 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 44721
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 6.83 | 6.83 |
| Practice Expense RVU | 1.66 | 1.66 |
| Malpractice RVU | 1.82 | 1.82 |
| Total RVU | 10.31 | 10.31 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 44721
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $334.88 | $334.88 | $325.36 - $365.76 | 29 |
| Florida | $402.09 | $402.09 | $372.5 - $439.58 | 3 |
| Georgia | $354.1 | $354.1 | $350.05 - $358.15 | 2 |
| Illinois | $398.67 | $398.67 | $373.76 - $424.96 | 4 |
| Michigan | $365.75 | $365.75 | $347.38 - $384.12 | 2 |
| North Carolina | $318.7 | $318.7 | $318.7 - $318.7 | 1 |
| New York | $383.45 | $383.45 | $323.54 - $421.54 | 5 |
| Ohio | $340.03 | $340.03 | $340.03 - $340.03 | 1 |
| Pennsylvania | $349.48 | $349.48 | $336.47 - $362.48 | 2 |
| Texas | $340.44 | $340.44 | $332.32 - $368.66 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 44721
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 44721 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 36591 | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 36592 | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
| 69990 | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 96523 | Column 1 (primary), can be billed with modifier | No | CPT Manual or CMS manual coding instruction |
Frequently Asked Questions, CPT 44721
What does CPT code 44721 mean? +
CPT code 44721 represents: Prep donor intestine/artery. It's in the Surgery (Digestive) category with a global period of XXX.
What is the Medicare reimbursement for CPT 44721? +
The 2026 Medicare national average non-facility payment for CPT 44721 is $342.69. Rates range from $299.97 to $439.58 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 44721? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 44721? +
This code has 4 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
Get the full PayerReady toolkit
Free access to CPT/ICD-10 lookup, denial appeals, fee comparator, and claim auditing with credentialing enrollment.
Start free →Run this code through our claim audit tool
Check NCCI bundling, MUE limits, and modifier logic before submission.
Try the auditor →Did this page help?
Quick signal so we know what to improve.
If you want a code reference page that doesn't exist yet, email coding@payerready.com.
Tell us what's missing or wrong: coding@payerready.com. We respond within 5 business days.
Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on April 17, 2026.
Powered by 11K CPT · 98K ICD-10 · 860K MPFS rates · 4.5M NCCI edits · 9.5M NPIs. Our data methodology · About our coding team