CPT 43101
Global 090 ActiveExcision of esophagus lesion
CPT 43101 Billing & Documentation Guide
CPT code 43101 (Excision of esophagus lesion) is classified under Surgery (Digestive) with a global period indicator of 090. The 2026 Medicare Physician Fee Schedule assigns a work RVU of 16.64, a non-facility practice expense RVU of 8.17, and a malpractice RVU of 4.19, a total non-facility RVU of 29 and facility RVU of 29. With the current conversion factor of $33.4009, the national average non-facility reimbursement is approximately $971.73, though rates vary from $860.32 to $1201.42 based on MAC locality and Geographic Practice Cost Indices (GPCIs).
When billing 43101, ensure documentation supports medical necessity and the specific components required for the code's level of service. For E/M codes, document MDM (medical decision-making) elements: problems addressed, data reviewed, and risk. For procedural codes, document the indication, technique, and any complications. Always verify NCCI edits before bundling 43101 with related codes; this code has 10 PTP bundling relationships on file (see table below).
Payment Status & Global Period
Active code (paid under MPFS)
90-day global period (major surgery: 1 day pre-op + procedure + 90 days post-op)
MUE Limit (Medically Unlikely Edits)
Submitting more than 1 units of 43101 for the same patient on the same date triggers automatic line denial unless an appropriate modifier and supporting documentation justify the higher quantity.
RVU Breakdown, CPT 43101
| Component | Non-Facility | Facility |
|---|---|---|
| Work RVU | 16.64 | 16.64 |
| Practice Expense RVU | 8.17 | 8.17 |
| Malpractice RVU | 4.19 | 4.19 |
| Total RVU | 29 | 29 |
| Conversion Factor | $33.4009 | |
2026 Medicare Reimbursement by State, CPT 43101
State-level averages across all MAC localities. Non-facility rates typically apply to office-based services; facility rates apply to hospital outpatient / inpatient.
| State | Non-Facility | Facility | Range (Non-Fac) | Localities |
|---|---|---|---|---|
| California | $974.5 | $974.5 | $939.33 - $1085.44 | 29 |
| Florida | $1102.02 | $1102.02 | $1027.01 - $1193.8 | 3 |
| Georgia | $984.41 | $984.41 | $966.02 - $1002.79 | 2 |
| Illinois | $1088.86 | $1088.86 | $1023.68 - $1155.12 | 4 |
| Michigan | $1009.01 | $1009.01 | $962.94 - $1055.08 | 2 |
| North Carolina | $899.82 | $899.82 | $899.82 - $899.82 | 1 |
| New York | $1076.84 | $1076.84 | $913.42 - $1175.71 | 5 |
| Ohio | $946 | $946 | $946 - $946 | 1 |
| Pennsylvania | $977.69 | $977.69 | $938.55 - $1016.83 | 2 |
| Texas | $957.5 | $957.5 | $934.13 - $1023.78 | 8 |
Source: CMS PFSRVU 2026 · Updated 2026-04-01. Full locality-level detail available for all 53 states, contact us for custom reports.
NCCI Bundling Edits, CPT 43101
Procedure-to-procedure (PTP) edits. If you bill any of these codes with 43101 on the same date of service, review the modifier indicator and payer policy before submission.
| Partner Code | Relationship | Modifier Allowed | Rationale |
|---|---|---|---|
| 0213T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0216T | Column 1 (primary), can be billed with modifier | No | Misuse of Column Two code with Column One code |
| 0228T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0230T | Column 1 (primary), can be billed with modifier | No | Standards of medical/surgical practice |
| 0596T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0597T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0708T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0709T | Column 1 (primary), can be billed with modifier | Yes | Standards of medical/surgical practice |
| 0903T | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
| 0904T | Column 1 (primary), can be billed with modifier | Yes | Misuse of Column Two code with Column One code |
Frequently Asked Questions, CPT 43101
What does CPT code 43101 mean? +
CPT code 43101 represents: Excision of esophagus lesion. It's in the Surgery (Digestive) category with a global period of 090.
What is the Medicare reimbursement for CPT 43101? +
The 2026 Medicare national average non-facility payment for CPT 43101 is $971.73. Rates range from $860.32 to $1201.42 across 53 states depending on MAC locality and GPCIs.
What modifiers can I use with CPT 43101? +
Surgery codes commonly use modifier 22 (increased procedural services), 50 (bilateral), 51 (multiple procedures), 52 (reduced services), 58/78/79 (staged, unplanned return, unrelated within global), 62 (co-surgeons), 80/82 (assistant surgeon), and 59 or the X{EPSU} subset for distinct procedural service.
What bundling edits apply to CPT 43101? +
This code has 10 NCCI PTP bundling relationships. See the NCCI Bundling section below for full list.
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Reviewed by the PayerReady Medical Coding Team
Verified against the CMS 2026 code set on June 1, 2026.
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